IL-4-Responsive B Cells Are Detrimental During Chronic Tuberculosis Infection in Mice

In tuberculosis, T cell-mediated immunity is extensively studied whilst B cells received limited attention in human and mice. Of interest, Mycobacterium tuberculosis ( Mtb ) does increase IL-4 Receptor-alpha (IL4Rα) expression in murine B cells. To better understand the role of IL4Rα signalling in B cells, we compared wild type mice with B cell-specific IL4Rα deficient mice (mb1 cre IL-4Rα -/lox mice). Chronic Mtb aerosol infection in mb1 cre...