ADAM7 promotes the proliferation and invasion in trophoblast cells

ADAMs are members of the metzincin family of zinc-dependent metalloproteinases, which play a key role in the proteolytic degradation of the extracellular matrix to invade cells. It is well known that ADAMs are involved in regulating the invasion of trophoblast cells. But the function and underlying mechanism of ADAM7 in trophoblast cells is still unknown. ADAM7 knockdown strongly inhibited HTR-8 and B6Tert-1 cells proliferation, migration and...