Y disruption, autosomal hypomethylation and poor male lung cancer survival
Abstract
Lung cancer is the most frequent cause of cancer death worldwide. It affects more men than women, and men generally have worse survival outcomes. We compared gene co-expression networks in affected and unaffected lung tissue from 126 consecutive patients with Stage IA-IV lung cancer undergoing surgery with curative intent. We observed marked degradation of a sex-associated transcription network in tumour tissue. This disturbance, detected in...
Paper Details
Title
Y disruption, autosomal hypomethylation and poor male lung cancer survival
Published Date
Jun 14, 2021
Journal
Volume
11
Issue
1
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