Effectiveness of physical exercise on the cardiovascular system in breast cancer patients: a systematic review and meta-analysis of randomized controlled trials.

Published on Jun 9, 2021in Complementary Therapies in Clinical Practice1.77
· DOI :10.1016/J.CTCP.2021.101426
OBJECTIVE The primary purpose of this study is to structure the available evidence relating to physical exercise programs and their impact on patients' cardiovascular system during the convalescence for breast cancer. METHODS We searched six English databases and four Chinese databases from inception to May 19, 2021. Two reviewers independently screened literature, extracted data. They assessed the risk of bias according to the eligibility criteria, and the Cochrane Collaboration RevMan 5.3.0 version software and STATA 15.0 software were used for this meta-analysis. This study has been registered in the International Prospective Register of Systematic Reviews (CRD42021226319). RESULTS In total, 3483 articles were screened and data from 11 randomized controlled trials (RCTs) involving 666 breast cancer patients were used in this meta-analysis. The results showed that exercise could decrease systolic blood pressure (SBP) (P = 0.006), diastolic blood pressure (DBP) (P = 0.0003), triglycerides (TG) levels (P   0.05). CONCLUSIONS Physical exercise could improve the cardiovascular system function associated with decreased the levels of SBP, DBP, TG, and increased the levels of VO2peak, VO2max, and HDL-C in breast cancer patients. These findings reveal that exercise may be a promising means for cardiovascular nursing.
#1Christina M. Dieli-Conwright (Harvard University)H-Index: 20
#2Frank S. Fox (SC: University of Southern California)H-Index: 1
Last. Kerry S. Courneya (U of A: University of Alberta)H-Index: 133
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#1Rui Guo (Guangxi Medical University)
#2Yu Chen (U.H.: University of Hawaii at Manoa)
Last. Youping Deng (U.H.: University of Hawaii at Manoa)H-Index: 1
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Lipids are essential components of cell structure and play important roles in signal transduction between cells and body metabolism. With the continuous development and innovation of lipidomics technology, many studies have shown that the relationship between lipids and cancer is steadily increasing, involving cancer occurrence, proliferation, migration, and apoptosis. Breast cancer has seriously affected the safety and quality of life of human beings worldwide and has become a significant publi...
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#1Martina E. Schmidt (DKFZ: German Cancer Research Center)H-Index: 23
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Last. Karen Steindorf (DKFZ: German Cancer Research Center)H-Index: 34
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#1Kellie TooheyH-Index: 5
#2Kate L. Pumpa (UC: University of Canberra)H-Index: 16
Last. Stuart SempleH-Index: 1
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Cardiovascular disease (CVD) remains the largest cause of death in breast cancer survivors. The aim of this study was to explore the impact of exercise intensity on aerobic fitness and autonomic cardiac regulation (heart rate variability (HRV)) and salivary biomarkers of the stress systems (HPA-axis, cortisol; sympathetic nervous system, α-amylase) and mucosal immunity (secretory(s)-IgA), markers of increased risk of CVD in breast cancer survivors. Participants were randomly assigned to; 1) high...
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#1Guilherme Fiori Maginador (State University of Campinas)H-Index: 1
#2Manoel E. Lixandrão (USP: University of São Paulo)H-Index: 13
Last. Miguel S. Conceição (State University of Campinas)H-Index: 12
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While performing aerobic exercise during chemotherapy has been proven feasible and safe, the efficacy of aerobic training on cardiorespiratory fitness (CRF) in women with breast cancer undergoing chemotherapy has not yet been systematically assessed. Therefore, the objective of this work was to determine (a) the efficacy of aerobic training to improve CRF; (b) the role of aerobic training intensity (moderate or vigorous) on CRF response; (c) the effect of the aerobic training mode (continuous or...
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#1Jessica M. Scott (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 29
#2Samantha M. Thomas (Duke University)H-Index: 27
Last. Lee W. Jones (Cornell University)H-Index: 14
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#1Lynnette M. Jones (University of Otago)H-Index: 13
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#1Hope S. Rugo (UCSF: University of California, San Francisco)H-Index: 107
Breast cancer is the most common cancer diagnosis in young women.1 In the United States, the incidence of breast cancer among women under the age of 50 is increasing by 0.2% per year, and the incid...
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#1Caragh FlanneryH-Index: 6
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