Single-dose versus short-course prophylactic antibiotics for peroral endoscopic myotomy: a randomized controlled trial

Background and Aims Peroral endoscopic myotomy (POEM) has been recommended for achalasia treatment. To prevent the potential of infective risk, antibiotic prophylaxis is usually administered, whereas the additional need of antibiotic therapy after POEM is uncertain. The primary endpoint was to determine whether prophylaxis versus prophylaxis plus short therapy was needed after POEM. Methods Consecutive patients scheduled for POEM were randomly...