Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A

Volume: 34, Pages: 79 - 91
Published: Dec 1, 2021
Abstract
Previously, we have reported a withanolide-type steroid, named tubocapsenolide A (TA), which shows potent anti-proliferative activity in several cancer cell lines. However, its inhibitory effect on the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway and therapeutic potential on osteosarcoma have not been reported.In the present study, we aimed to investigate the effect and molecular mechanism of TA in...
Paper Details
Title
Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A
Published Date
Dec 1, 2021
Volume
34
Pages
79 - 91
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