Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets
Abstract
Dextromethorphan (DXM) acts as cough suppressant via its central action. Cell-protective effects of this drug have been reported in peripheral tissues, making DXM potentially useful for treatment of several common human diseases, such as type 2 diabetes mellitus (T2DM). Pancreatic islets are among the peripheral tissues that positively respond to DXM, and anti-diabetic effects of DXM were observed in two placebo-controlled, randomized clinical...
Paper Details
Title
Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets
Published Date
Oct 1, 2021
Journal
Volume
28
Issue
10
Pages
1474 - 1488.e7
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