Prognostic impact of XPO1 mutations in metastatic non-small cell lung cancer (NSCLC).

Volume: 39, Issue: 15_suppl, Pages: e20533 - e20533
Published: May 20, 2021
Abstract
e20533 Background: Nuclear protein transport is essential in guiding the organized traffic of important proteins and RNAs between the nucleus and cytoplasm of the cell. Export of proteins from the nucleus is exclusively regulated by Exportin 1(XPO1). In cancer, XPO1 is universally hyperactive and can promote the export of important tumor suppressors to the cytoplasm, leading to their functional inactivation. XPO1 is aberrantly over expressed in...
Paper Details
Title
Prognostic impact of XPO1 mutations in metastatic non-small cell lung cancer (NSCLC).
Published Date
May 20, 2021
Volume
39
Issue
15_suppl
Pages
e20533 - e20533
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