Patisiran Stabilizes Cardiac Mechanics in Patients with Hereditary Transthyretin-Mediated Amyloidosis: Post-hoc Analysis of the APOLLO Study

Hereditary transthyretin-mediated (hATTR) amyloidosis is caused by deposition of transthyretin (TTR) fibrils in the heart, nerves and other organs. Patisiran is a siRNA that inhibits hepatic synthesis of TTR. This post-hoc analysis used single-beat pressure-volume (PV) techniques to delineate the effects of patisiran on cardiac function in the APOLLO trial. Noninvasive PV loops were constructed from core laboratory echocardiograms using LV...