Using poro-elasticity to model the large deformation of tissue during subcutaneous injection

Subcutaneous injection of therapeutic monoclonal antibodies (mAbs) has recently attracted unprecedented interests in the pharmaceutical industry. The drug transport in the tissue and mechanical response of the tissue after injection are not yet well-understood. We are motivated to study subcutaneous injection using poro-elasticity, including linear and nonlinear poro-elastic models. We first present the fixed-stress split of the nonlinear model...