Using poro-elasticity to model the large deformation of tissue during subcutaneous injection

Published on Oct 1, 2021in Computer Methods in Applied Mechanics and Engineering5.763
· DOI :10.1016/J.CMA.2021.113919
Yu Leng1
Estimated H-index: 1
(Purdue University),
Yu Leng6
Estimated H-index: 6
(Purdue University)
Source
Abstract
Abstract null null Subcutaneous injection of therapeutic null monoclonal antibodies null null null (mAbs) has recently attracted unprecedented interests in the pharmaceutical industry. The drug transport in the tissue and mechanical response of the tissue after injection are not yet well-understood. We are motivated to study subcutaneous injection using poro-elasticity, including linear and nonlinear poro-elastic models. We first present the fixed-stress split of the null nonlinear model null and perform convergence studies under spatial and temporal refinements. We then investigate the model assumption of the linear model using numerical solutions. In the case of small permeability, the linear model is not adequate to account for the null null large deformation null of the tissue due to injection. Next, we adopt a nonlinear poro-elastic model to study subcutaneous injection. For large deformation, numerical solutions of the nonlinear model differ significantly from that of the linear model, especially near the injection site.
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Cited By1
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#1Yu Leng (Purdue University)H-Index: 1
#1Yu Leng (Purdue University)H-Index: 6
Last. Hector Gomez (Purdue University)H-Index: 42
view all 3 authors...
Abstract null null Subcutaneous delivery of therapeutic monoclonal antibodies (mAbs) has recently attracted exceptional interests in the pharmaceutical industry. The mechanical response of the tissue during the injection and the drug distribution after the injection are yet to be understood. We are motivated to study the subcutaneous injection using a nonlinear poro-elastic model with a viscoelastic constitutive law of the solid. The model is first validated against experimental data of relaxati...
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