Umbrella review of 42 systematic reviews with meta‐analyses: the safety of proton pump inhibitors

Proton pump inhibitors (PPIs) are widely used to treat and prevent acid-related disorders. Despite high efficacy, PPI safety has been increasingly scrutinised. However, no comprehensive review summarising investigations of various adverse events is available.To perform an umbrella review to comprehensively assess associations between adverse events and PPI use.In accordance with PRISMA, an umbrella review of systematic reviews with meta-analyses...