Design, synthesis, and evaluation of peptide‐imidazo[1,2‐ a ]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525
Abstract
Helicobacter pylori (H. pylori) infections have been implicated in the development of gastric ulcers and various cancers: however, the success of current therapies is compromised by rising antibiotic resistance. The virulence and pathogenicity of H. pylori is mediated by the type IV secretion system (T4SS), a multiprotein macromolecular nanomachine that transfers toxic bacterial factors and plasmid DNA between bacterial cells, thus contributing...
Paper Details
Title
Design, synthesis, and evaluation of peptide‐imidazo[1,2‐ a ]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525
Published Date
Jun 17, 2021
Journal
Volume
27
Issue
10
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