Switching on prodrugs using radiotherapy
Abstract
Chemotherapy is a powerful tool in the armoury against cancer, but it is fraught with problems due to its global systemic toxicity. Here we report the proof of concept of a chemistry-based strategy, whereby gamma/X-ray irradiation mediates the activation of a cancer prodrug, thereby enabling simultaneous chemo-radiotherapy with radiotherapy locally activating a prodrug. In an initial demonstration, we show the activation of a fluorescent probe...
Paper Details
Title
Switching on prodrugs using radiotherapy
Published Date
Jun 10, 2021
Journal
Volume
13
Issue
8
Pages
805 - 810
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Notes
History