An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein
Abstract
Neuropathological and experimental evidence suggests that the cell-to-cell transfer of α-synuclein has an important role in the pathogenesis of Parkinson's disease (PD). However, the mechanism underlying this phenomenon is not fully understood. We undertook a small interfering RNA (siRNA), genome-wide screen to identify genes regulating the cell-to-cell transfer of α-synuclein. A genetically encoded reporter, GFP-2A-αSynuclein-RFP, suitable for...
Paper Details
Title
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein
Published Date
Jun 1, 2021
Journal
Volume
35
Issue
10
Pages
109189 - 109189
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