Landscape and selection of vaccine epitopes in SARS-CoV-2

Early in the pandemic, we designed a SARS-CoV-2 peptide vaccine containing epitope regions optimized for concurrent B cell, CD4+ T cell, and CD8+ T cell stimulation. The rationale for this design was to drive both humoral and cellular immunity with high specificity while avoiding undesired effects such as antibody-dependent enhancement (ADE).We explored the set of computationally predicted SARS-CoV-2 HLA-I and HLA-II ligands, examining protein...