Biomimetic gelatin/chitosan/polyvinyl alcohol/nano-hydroxyapatite scaffolds for bone tissue engineering

Multi-component bone tissue engineering scaffolds are the dominant trend to address complex requirements of bone defect repair. In this study, to mimic component and microstructure of natural bone, polymers (natural and synthetic) and nano-hydroxyapatite (nHAp) were fabricated to form a porous composite scaffold. Gelatin (Gel), chitosan (CS) and polyvinyl alcohol (PVA) were first assembled to simulate extracellular matrix. The simulated matrix...