Impaired DNA Repair Fidelity in a Breast Cancer Patient With Adverse Reactions to Radiotherapy
Abstract
We tested the hypothesis that differences in DNA double-strand break (DSB) repair fidelity underlies differences in individual radiosensitivity and, consequently, normal tissue reactions to radiotherapy. Fibroblast cultures derived from a radio-sensitive (RS) breast cancer patient with grade 3 adverse reactions to radiotherapy were compared with normal control (NC) and hyper-radiosensitive ataxia-telangiectasia mutated (ATM) cells. DSB repair...
Paper Details
Title
Impaired DNA Repair Fidelity in a Breast Cancer Patient With Adverse Reactions to Radiotherapy
Published Date
Jun 7, 2021
Journal
Volume
9
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