CCR2-engineered mesenchymal stromal cells accelerate diabetic wound healing by restoring immunological homeostasis
Abstract
Impaired wound healing presents great health risks to patients. While encouraging, the current clinical successes of mesenchymal stromal cell (MSC)-based therapies for tissue repair have been limited. Genetic engineering could endow MSCs with more robust regenerative capacities. Here, we identified that C-C motif chemokine receptor 2 (CCR2) overexpression enhanced the targeted migration and immunoregulatory potential of MSCs in response to C-C...
Paper Details
Title
CCR2-engineered mesenchymal stromal cells accelerate diabetic wound healing by restoring immunological homeostasis
Published Date
Aug 1, 2021
Journal
Volume
275
Pages
120963 - 120963
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