Dysregulation of epidermal barrier in mouse skin wounds induced by sulfur mustard

Sulfur mustard (2,2′-dichlorodiethyl sulfide, SM), is a potent chemical vesicant. Skin exposure to SM results in blistering, persistent epidermal hyperplasia, severe tissue damage, and prolonged wound repairs. SM, a bifunctional alkylating agent, causes DNA damage in mouse skin cells; however, the mechanistic action of SM in tissue injuries is still unclear. Studies showed mouse skin following SM exposure activates several stress signaling...