Evaluación de la prueba Fluorecare de anticuerpos contra la proteína Spike del SARS-CoV-2 en la práctica real

Published on Jun 14, 2021
· DOI :10.1515/ALMED-2021-0050
#1Victoria Gniazdowski (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
#2C. Paul Morris (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 6
Last. Heba H. Mostafa (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 16
view all 15 authors...
BACKGROUND: Repeat COVID-19 molecular testing can lead to positive test results after negative tests and to multiple positive test results over time. The association between positive tests and infectious virus is important to quantify. METHODS: A two months cohort of retrospective data and consecutively collected specimens from COVID-19 patients or patients under investigation were used to understand the correlation between prolonged viral RNA positive test results, cycle threshold (Ct) values a...
49 CitationsSource
#1Claudia Alteri (University of Milan)H-Index: 18
#2Valeria Cento (University of Milan)H-Index: 19
Last. Carlo Federico Perno (University of Milan)H-Index: 75
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9 CitationsSource
#1Mary Kathryn Bohn (U of T: University of Toronto)H-Index: 7
#2Giuseppe LippiH-Index: 109
Last. Ifcc Taskforce on CovidH-Index: 1
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With an almost unremittent progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections all around the world, there is a compelling need to introduce rapid, reliable, and high-throughput testing to allow appropriate clinical management and/or timely isolation of infected individuals. Although nucleic acid amplification testing (NAAT) remains the gold standard for detecting and theoretically quantifying SARS-CoV-2 mRNA in various specimen types, antigen assays may be con...
5 CitationsSource
#1Ashish Goyal (Fred Hutchinson Cancer Research Center)H-Index: 9
#2Daniel B. Reeves (Fred Hutchinson Cancer Research Center)H-Index: 17
Last. Bryan T. Mayer (Fred Hutchinson Cancer Research Center)H-Index: 12
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SARS-CoV-2 is difficult to contain because many transmissions occur during pre-symptomatic infection. Unlike influenza, most SARS-CoV-2 infected people do not transmit while a small percentage infect large numbers of people. We designed mathematical models which link observed viral loads with epidemiologic features of each virus, including distribution of transmissions attributed to each infected person and duration between symptom onset in the transmitter and secondarily infected person. We ide...
20 CitationsSource
#1Camilla MattiuzziH-Index: 23
#2Brandon Michael Henry (Cincinnati Children's Hospital Medical Center)H-Index: 33
Last. Giuseppe Lippi (University of Verona)H-Index: 109
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Although the most effective strategy for preventing or containing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks relies on early diagnosis, the paramount and unprecedented number of tests needed to fully achieve this target is overwhelming worldwide testing supply and capacity. Molecular detection of SARS-CoV-2 RNA in nasopharyngeal swabs is still considered the reference diagnostic approach. Nonetheless, identification of SARS-CoV-2 proteins in upper respiratory tract sp...
10 CitationsSource
#1Giuseppe LippiH-Index: 109
2 CitationsSource
#1Lars F. Westblade (Cornell University)H-Index: 32
#2Gagandeep Brar (Cornell University)H-Index: 10
Last. Michael J. Satlin (Cornell University)H-Index: 30
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Patients with cancer may be at increased risk of severe coronavirus disease 2019 (COVID-19), but the role of viral load on this risk is unknown. We measured SARS-CoV-2 viral load using cycle threshold (CT) values from reverse-transcription polymerase chain reaction assays applied to nasopharyngeal swab specimens in 100 patients with cancer and 2,914 without cancer who were admitted to three New York City hospitals. Overall, the in-hospital mortality rate was 38.8% among patients with a high vira...
80 CitationsSource
#1Elisabet Pujadas (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 8
#2Fayzan Chaudhry (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 6
Last. Carlos Cordon-Cardo (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 71
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Abstract The need for reliable and widely available SARS-CoV-2 testing is well recognized, but it will be equally necessary to develop quantitative methods that determine viral load in order to guide patient triage and medical decision making. We are the first to report that SARS-CoV-2 viral load at the time of presentation is an independent predictor of COVID-19 mortality in a large patient cohort (n=1,145). Viral loads should be used to identify higher-risk patients that may require more aggre...
199 CitationsSource
#1Jacqueline Dinnes (University of Birmingham)H-Index: 26
#2Jonathan J Deeks (University of Birmingham)H-Index: 116
Last. Ann Van den Bruel (Katholieke Universiteit Leuven)H-Index: 24
view all 19 authors...
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting COVID-19 pandemic present important diagnostic challenges. Several diagnostic strategies are available to identify or rule out current infection, identify people in need of care escalation, or to test for past infection and immune response. Point-of-care antigen and molecular tests to detect current SARS-CoV-2 infection have the potential to allow earlier detection and isolation of confirmed cases compared ...
292 CitationsSource
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