Cancer cell migration in collagen-hyaluronan composite extracellular matrices

Volume: 130, Pages: 183 - 198
Published: Aug 1, 2021
Abstract
Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness. While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery. The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA...
Paper Details
Title
Cancer cell migration in collagen-hyaluronan composite extracellular matrices
Published Date
Aug 1, 2021
Volume
130
Pages
183 - 198
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