Association of the collagen score with anastomotic leakage in rectal cancer patients after neoadjuvant chemoradiotherapy

Abstract

Background

Collagen changes in the extracellular matrix caused by neoadjuvant chemoradiotherapy are a potential mechanism of anastomotic leakage. We aimed to construct a fully quantitative collagen score to describe collagen structure changes in the extracellular matrix and then develop and validate a prediction model to identify patients who are at a high risk of postoperative anastomotic leakage.

Methods

This...