Non‐steroidal anti‐inflammatory drugs, polygenic risk score and colorectal cancer risk

Summary Background The regular use of non‐steroidal anti‐inflammatory drugs (NSAIDs) has been associated with reduced colorectal cancer (CRC) risk. Aim To explore whether this association varies according to background polygenic risk for CRC. Methods Data were collected from a large population‐based case‐control study on CRC in Germany. A polygenic risk score (PRS) based on 140 CRC‐related risk loci was used to quantify the genetic risk. The...