Accelerated aging in normal breast tissue of women with breast cancer
Abstract
DNA methylation alterations have similar patterns in normal aging tissue and in cancer. In this study, we investigated breast tissue-specific age-related DNA methylation alterations and used those methylation sites to identify individuals with outlier phenotypes. Outlier phenotype is identified by unsupervised anomaly detection algorithms and is defined by individuals who have normal tissue age-dependent DNA methylation levels that vary...
Paper Details
Title
Accelerated aging in normal breast tissue of women with breast cancer
Published Date
May 22, 2021
Journal
Volume
23
Issue
1
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