An optogenetic method for interrogating YAP1 and TAZ nuclear–cytoplasmic shuttling
Abstract
The shuttling of transcription factors and transcriptional regulators into and out of the nucleus is central to the regulation of many biological processes. Here we describe a new method for studying the rates of nuclear entry and exit of transcriptional regulators. A photo-responsive LOV (light-oxygen-voltage) domain from Avena sativa is used to sequester fluorescently labelled transcriptional regulators YAP1 and TAZ (also known as WWTR1) on...
Paper Details
Title
An optogenetic method for interrogating YAP1 and TAZ nuclear–cytoplasmic shuttling
Published Date
Jul 1, 2021
Journal
Volume
134
Issue
13
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