CONNed in Pregnancy.

Published on Jun 1, 2021in Hypertension7.713
· DOI :10.1161/HYPERTENSIONAHA.121.17021
Spoorthy Kulkarni3
Estimated H-index: 3
(Cambridge University Hospitals NHS Foundation Trust),
Anna F. Dominiczak115
Estimated H-index: 115
+ 8 AuthorsIan B. Wilkinson29
Estimated H-index: 29
(University of Cambridge)
#1Skand Shekhar (NIH: National Institutes of Health)H-Index: 5
#2Rasha Haykal (NIH: National Institutes of Health)
Last. Fady Hannah-Shmouni (NIH: National Institutes of Health)H-Index: 14
view all 5 authors...
Summary A 29-year-old primigravida woman with a known history of primary aldosteronism due to a right aldosteronoma presented with uncontrolled hypertension at 5 weeks of estimated gestation of a spontaneous pregnancy. Her hypertension was inadequately controlled with pharmacotherapy which lead to the consideration of surgical management for her primary aldosteronism. She underwent curative right unilateral adrenalectomy at 19 weeks of estimated gestational age. The procedure was uncomplicated, ...
1 CitationsSource
#1Caitlin Kilmartin (U of T: University of Toronto)H-Index: 1
#2Touhid Opu (MUHC: McGill University Health Centre)H-Index: 1
Last. Natalie Dayan (McGill University)H-Index: 13
view all 4 authors...
: We present a case of persistent postpartum hypertension found to be secondary to primary hyperaldosteronism in a woman with a history of recurrent hypertensive disorders of pregnancy and associated fetal complications. Our systematic review revealed only 18 cases of primary aldosteronism diagnosed in women with postpartum hypertension, suggesting that this disorder is under-studied in the postpartum period. A review of these cases suggests that women with primary hyperaldosteronism commonly pr...
5 CitationsSource
#1Ester Landau (Paris V: Paris Descartes University)H-Index: 1
#2Laurence AmarH-Index: 41
Hypertension (HT) is a complication of 8% of all pregnancies and 10% of HT cases are due to primary aldosteronism (PA). There is very little data on PA and pregnancy. Given the changes in the renin angiotensin system during pregnancy, the diagnosis of PA is difficult to establish during gestation. It may be suspected in hypertensive patients with hypokalemia. A comprehensive literature review identified reports covering 40 pregnancies in patients suffering from PA. Analysis of these cases shows ...
17 CitationsSource
#1Kirun Gunganah (St Bartholomew's Hospital)H-Index: 5
#2Robert Carpenter (St Bartholomew's Hospital)H-Index: 20
Last. William M Drake (St Bartholomew's Hospital)H-Index: 29
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A 31‐year‐old woman was referred to our unit 10 weeks into in her fifth pregnancy. She had a complex obstetric history: following an uneventful first pregnancy aged 22, she subsequently had a stillbirth at 32 weeks, a spontaneous abortion at 15 weeks, and a neonatal death following an emergency cesarean section for pre‐eclampsia at 34 weeks. Hypertension was found in, and persisted after, her second pregnancy but clinical details from her native Ghana were scarce. Our investigations revealed hyp...
11 CitationsSource
#1Adam Morton (Mater Health Services)H-Index: 10
Abstract Primary aldosteronism is the most common cause of secondary hypertension. Less than 50 cases of pregnancy in women with primary aldosteronism have been reported, suggesting the disorder is significantly underdiagnosed in confinement. Accurate diagnosis is complicated by physiological changes in the renin–angiotensin–aldosterone axis in pregnancy, leading to a risk of false negative results on screening tests. The course of primary aldosteronism during pregnancy is highly variable, altho...
20 CitationsSource
#1Robert Krysiak (University of Silesia in Katowice)H-Index: 25
#1R Krysiak (University of Silesia in Katowice)H-Index: 1
Last. R StojkoH-Index: 3
view all 3 authors...
AbstractWe describe a case of primary aldosteronism secondary to bilateral adrenal hyperplasia in three subsequent pregnancies. The disease was diagnosed soon after the first pregnancy, which ended in a miscarriage, and was treated pharmacologically with spironolactone. Because spironolactone is contraindicated in pregnancy, while the hypotensive effects of methyldopa, hydralazine, labetalol, diazoxide and nifedipine were unsatisfactory, in the second (since week 14) and third (since week 6) pre...
15 CitationsSource
#1Vanessa Ronconi (Marche Polytechnic University)H-Index: 19
#2Federica Turchi (Marche Polytechnic University)H-Index: 11
Last. Gilberta Giacchetti (Marche Polytechnic University)H-Index: 38
view all 5 authors...
19 CitationsSource
#1Kinshi Kosaka (OCU: Osaka City University)H-Index: 5
#2Naoyoshi Onoda (OCU: Osaka City University)H-Index: 29
Last. Kosei Hirakawa (OCU: Osaka City University)H-Index: 69
view all 10 authors...
A pregnant 26-year-old woman was referred for evaluation and management of progressive hypertension and hypokalemia at 14 weeks of gestation. Her plasma aldosterone level was markedly elevated and magnetic resonance imaging showed a right adrenal tumor. Primary aldosteronism due to an aldosterone producing-adenoma was diagnosed. Because of progressive severe hypertension, a laparoscopic adrenalectomy was performed at 17 weeks of gestation. The procedure was completed without complication, and pl...
25 CitationsSource
Background: Bartter’s syndrome is a rare condition during pregnancy. The prenatal management is difficult to maintain normal potassium serum levels. Case: We describe a 26-year-old woman with Bartter’s syndrome. During pregnancy, she required increasing potassium and magnesium supplementations. Amiloride, a sparing potassium diuretic, was continued. She delivered an unaffected girl at term. Conclusion: When Bartter’s syndrome is associated with pregnancy, the management must be careful. Amilorid...
21 CitationsSource
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