Targeted mutagenesis in mouse cells and embryos using an enhanced prime editor.
Abstract
Prime editors, novel genome-editing tools consisting of a CRISPR-Cas9 nickase and an engineered reverse transcriptase, can induce targeted mutagenesis. Nevertheless, much effort is required to optimize and improve the efficiency of prime-editing. Herein, we introduce two strategies to improve the editing efficiency using proximal dead sgRNA and chromatin-modulating peptides. We used enhanced prime-editing to generate Igf2 mutant mice with...
Paper Details
Title
Targeted mutagenesis in mouse cells and embryos using an enhanced prime editor.
Published Date
Jun 3, 2021
Journal
Volume
22
Issue
1
Pages
170 - 170
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