The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
Abstract
T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In the absence of the eukaryotic type II chaperonin complex, CCT, T cell activation induced changes in the proteome are compromised including the formation of nuclear actin filaments and the formation of a normal cell stress response. Consequently, thymocyte maturation and selection, and T cell...
Paper Details
Title
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
Published Date
Jun 3, 2021
Journal
Volume
4
Issue
1
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