PAC1 receptor–mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain
Abstract
Accumulation of pathological tau in synapses has been identified as an early event in Alzheimer's disease (AD) and correlates with cognitive decline in patients with AD. Tau is a cytosolic axonal protein, but under disease conditions, tau accumulates in postsynaptic compartments and presynaptic terminals, due to missorting within neurons, transsynaptic transfer between neurons, or a failure of clearance pathways. Using subcellular fractionation...
Paper Details
Title
PAC1 receptor–mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain
Published Date
May 26, 2021
Volume
13
Issue
595
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