Efficient Labeling of Native Human IgG by Proximity-Based Sortase-Mediated Isopeptide Ligation
Abstract
Antibody-drug conjugates (ADCs) have demonstrated great therapeutic potential due to their ability to target the delivery of potent cytotoxins. However, the heterogeneous nature of conventional drug conjugation strategies can affect the safety, efficacy, and stability of ADCs. Site-specific conjugations can resolve these issues, but often require genetic modification of Immunoglobulin G (IgG), which can impact yield or cost of production, or...
Paper Details
Title
Efficient Labeling of Native Human IgG by Proximity-Based Sortase-Mediated Isopeptide Ligation
Published Date
May 24, 2021
Journal
Volume
32
Issue
6
Pages
1058 - 1066
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