Interleukin-2 PET imaging in patients with metastatic melanoma before and during immune checkpoint inhibitor therapy

Volume: 48, Issue: 13, Pages: 4369 - 4376
Published: Jun 2, 2021
Abstract
Immune checkpoint inhibitors can induce a T cell-mediated anti-tumor immune response in patients with melanoma. Visualizing T cell activity using positron emission tomography (PET) might allow early insight into treatment efficacy. Activated tumor-infiltrating T cells express the high-affinity interleukin-2 receptor (IL-2R). Therefore, we performed a pilot study, using fluorine-18-labeled IL-2 ([18F]FB-IL2 PET), to evaluate whether a...
Paper Details
Title
Interleukin-2 PET imaging in patients with metastatic melanoma before and during immune checkpoint inhibitor therapy
DOI
Published Date
Jun 2, 2021
Journal
Volume
48
Issue
13
Pages
4369 - 4376
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