Is the Age of Extended Pelvic Lymph Node Dissection Over? The Devil Is in the Details.

Published on May 25, 2021in European Urology Oncology
· DOI :10.1016/J.EUO.2021.05.001
Gaëtan Devos10
Estimated H-index: 10
(Katholieke Universiteit Leuven),
Andries Clinckaert1
Estimated H-index: 1
(Katholieke Universiteit Leuven)
+ 1 AuthorsSteven Joniau73
Estimated H-index: 73
(Katholieke Universiteit Leuven)
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Abstract Background The role of extended pelvic lymph node dissection (EPLND) in the surgical management of prostate cancer (PCa) patients remains controversial, mainly because of a lack of randomized controlled trials (RCTs). Objective To determine whether EPLND has better oncological outcomes than limited PLND (LPLND. Design, setting and participants This was a prospective, single-center phase 3 trial in patients with intermediate- or high-risk clinically localized PCa. Intervention Randomizat...
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Abstract Background Pelvic lymph node dissection (PLND) is the most reliable procedure for lymph node staging. However, the therapeutic benefit remains unproven; although most radical prostatectomies at academic centers are accompanied by PLND, there is no consensus regarding the optimal anatomical extent of PLND. Objective To evaluate whether extended PLND results in a lower biochemical recurrence rate. Design, setting, and participants We conducted a single-center randomized trial. Patients, e...
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Summary Background The international Intermediate Clinical Endpoints in Cancer of the Prostate working group has established metastasis-free survival as a surrogate for overall survival in localised prostate cancer based on the findings of 19 predominantly radiotherapy-based trials. We sought to comprehensively assess aggregate trial-level performance of commonly reported intermediate clinical endpoints across all randomised trials in localised prostate cancer. Methods For this meta-analysis, we...
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PURPOSEWe report the clinical outcomes of a randomized trial comparing prophylactic whole-pelvic nodal radiotherapy to prostate-only radiotherapy (PORT) in high-risk prostate cancer.METHODSThis pha...
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#1Lorenzo Tosco (Katholieke Universiteit Leuven)H-Index: 13
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Abstract Background Accurate prediction of survival after radical prostatectomy (RP) is important for making decisions regarding multimodal therapies. There is a lack of tools to predict prostate cancer–related death (PCRD) in patients with high-risk features. Objective To develop and validate a prognostic model that predicts PCRD combining pathologic features and using competing-risks analysis. Design, setting, and participants This was a retrospective multi-institutional observational cohort s...
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