Is the Age of Extended Pelvic Lymph Node Dissection Over? The Devil Is in the Details.

Published on May 25, 2021in European Urology Oncology
· DOI :10.1016/J.EUO.2021.05.001
Gaëtan Devos10
Estimated H-index: 10
(Katholieke Universiteit Leuven),
Andries Clinckaert1
Estimated H-index: 1
(Katholieke Universiteit Leuven)
+ 1 AuthorsSteven Joniau73
Estimated H-index: 73
(Katholieke Universiteit Leuven)
📖 Papers frequently viewed together
1 Author (S. Duke Herrell)
2 Citations
1 Citations
#1Jean F.P. Lestingi (USP: University of São Paulo)H-Index: 4
#2Giuliano Guglielmetti (USP: University of São Paulo)H-Index: 11
Last. William C. Nahas (USP: University of São Paulo)H-Index: 21
view all 12 authors...
Abstract Background The role of extended pelvic lymph node dissection (EPLND) in the surgical management of prostate cancer (PCa) patients remains controversial, mainly because of a lack of randomized controlled trials (RCTs). Objective To determine whether EPLND has better oncological outcomes than limited PLND (LPLND. Design, setting and participants This was a prospective, single-center phase 3 trial in patients with intermediate- or high-risk clinically localized PCa. Intervention Randomizat...
3 CitationsSource
#1Karim Touijer (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 46
#2Daniel Sjöberg (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 42
Last. Andrew J. Vickers (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 125
view all 8 authors...
Abstract Background Pelvic lymph node dissection (PLND) is the most reliable procedure for lymph node staging. However, the therapeutic benefit remains unproven; although most radical prostatectomies at academic centers are accompanied by PLND, there is no consensus regarding the optimal anatomical extent of PLND. Objective To evaluate whether extended PLND results in a lower biochemical recurrence rate. Design, setting, and participants We conducted a single-center randomized trial. Patients, e...
1 CitationsSource
#1Laila A. Gharzai (UM: University of Michigan)H-Index: 5
#2Ralph Jiang (UM: University of Michigan)H-Index: 1
Last. Daniel E. Spratt (UM: University of Michigan)H-Index: 50
view all 25 authors...
Summary Background The international Intermediate Clinical Endpoints in Cancer of the Prostate working group has established metastasis-free survival as a surrogate for overall survival in localised prostate cancer based on the findings of 19 predominantly radiotherapy-based trials. We sought to comprehensively assess aggregate trial-level performance of commonly reported intermediate clinical endpoints across all randomised trials in localised prostate cancer. Methods For this meta-analysis, we...
1 CitationsSource
#1Vedang Murthy (HBNI: Homi Bhabha National Institute)H-Index: 26
#1Vedang Murthy (HBNI: Homi Bhabha National Institute)H-Index: 6
Last. Umesh Mahantshetty (HBNI: Homi Bhabha National Institute)H-Index: 26
view all 20 authors...
PURPOSEWe report the clinical outcomes of a randomized trial comparing prophylactic whole-pelvic nodal radiotherapy to prostate-only radiotherapy (PORT) in high-risk prostate cancer.METHODSThis pha...
2 CitationsSource
#1Lorenzo Tosco (Katholieke Universiteit Leuven)H-Index: 13
#2Annouschka Laenen (Katholieke Universiteit Leuven)H-Index: 23
Last. Steven Joniau (Katholieke Universiteit Leuven)H-Index: 73
view all 26 authors...
Abstract Background Accurate prediction of survival after radical prostatectomy (RP) is important for making decisions regarding multimodal therapies. There is a lack of tools to predict prostate cancer–related death (PCRD) in patients with high-risk features. Objective To develop and validate a prognostic model that predicts PCRD combining pathologic features and using competing-risks analysis. Design, setting, and participants This was a retrospective multi-institutional observational cohort s...
10 CitationsSource
#1Lisa Moris (Katholieke Universiteit Leuven)H-Index: 11
#2Thomas Van den Broeck (Katholieke Universiteit Leuven)H-Index: 21
Last. Steven Joniau (Katholieke Universiteit Leuven)H-Index: 73
view all 28 authors...
Aim: To determine the impact of the extent of lymph node invasion (LNI), on long-term oncological outcomes after radical prostatectomy (RP). Material and methods: In this retrospective study we examined the data of 1249 high-risk, non-metastatic PCa patients treated with RP and pelvic lymph node dissection (PLND) between 1989 and 2011 at 8 different tertiary institutions. We fitted univariate and multivariate cox models to assess independent predictors of cancer specific survival (CSS) and overa...
10 CitationsSource
Cited By0