A novel CXCR4 antagonist counteracts paradoxical generation of cisplatin-induced pro-metastatic niches in lung cancer

Volume: 29, Issue: 10, Pages: 2963 - 2978
Published: Oct 1, 2021
Abstract
Platinum-based chemotherapy remains widely used in advanced non-small cell lung cancer (NSCLC) despite experimental evidence of its potential to induce long-term detrimental effects, including the promotion of pro-metastatic microenvironments. In this study, we investigated the interconnected pathways underlying the promotion of cisplatin-induced metastases.In tumor-free mice, cisplatin treatment resulted in an expansion in the bone marrow of...
Paper Details
Title
A novel CXCR4 antagonist counteracts paradoxical generation of cisplatin-induced pro-metastatic niches in lung cancer
Published Date
Oct 1, 2021
Volume
29
Issue
10
Pages
2963 - 2978
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