The Rhox gene cluster suppresses germline LINE1 transposition

Abstract
Transposable elements (TEs) are mobile sequences that engender widespread mutations and thus are a major hazard that must be silenced. The most abundant active class of TEs in mammalian genomes is long interspersed element class 1 (LINE1). Here, we report that LINE1 transposition is suppressed in the male germline by transcription factors encoded by a rapidly evolving X-linked homeobox gene cluster. LINE1 transposition is repressed by many...
Paper Details
Title
The Rhox gene cluster suppresses germline LINE1 transposition
Published Date
Jun 3, 2021
Volume
118
Issue
23
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