NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice
Abstract
Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal-induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with upregulated caspase 1 protease and IL-1β in macrophages. Cucurbitacin B (CuB) is a tetracyclic triterpene that possesses a potential anti-inflammatory activity. However, the immunomodulatory and...
Paper Details
Title
NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice
Published Date
Aug 1, 2021
Volume
67
Issue
2
Pages
27 - 40
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