Multiresistant bacteria isolated from domestic and wild animals with skin lesions were susceptible to native plants from Southern Brazil.

Published on Jun 2, 2021in Natural Product Research2.158
· DOI :10.1080/14786419.2021.1933972
Claudia Giordani1
Estimated H-index: 1
(UCS: University of Caxias do Sul),
Stefanie Bressan Waller8
Estimated H-index: 8
(UFPEL: Universidade Federal de Pelotas)
+ 9 AuthorsMarlete Brum Cleff12
Estimated H-index: 12
(UFPEL: Universidade Federal de Pelotas)
Sources
Abstract
We evaluated the chemical composition, toxicity, and antibacterial activity of Schinus terebinthifolia (SCH), Eugenia uniflora (EUG), Persicaria hydropiperoides (PER), Equisetum hyemale (EQU), Solidago chilensis (SOL), and Baccharis trimera (BRA). These plants were tested (7.5-0.01 mg/mL) against Gram-positive (G+; n = 32) and Gram-negative (G-; n = 26) isolates from animals (M07-A9, CLSI). Antibiogram (disk diffusion), chromatographic analysis (UPLC), and toxicity assay (HET-CAM) were also performed. A high incidence of resistance was noted, in which 18.4% (07/38) of G+ (Staphylococcus intermedius/Enterococcus faecium) and 17.7% (06/34) of G- (Pseudomonas aeruginosa/Escherichia coli/Proteus mirabilis) were multidrug-resistant. All bacteria were sensitive (MIC50) to SCH (both 3.75 mg/mL), EUG (3.75 mg/mL and 7.5 mg/mL, respectively) and PER (both 7.5 mg/mL). SCH/EUG/PER highlighted as antibacterial, probably due to the major compounds (ethyl gallate, quinic acid, quercetin). These extracts showed normal embryonic development (SCH/EUG: 7.5-0.94 mg/mL). These findings highlighted the promising use of native plants for therapeutic purposes.
📖 Papers frequently viewed together
35 Citations
9 Citations
References12
Newest
#1Arijit Pal (Calcutta School of Tropical Medicine)H-Index: 4
#2Anusri Tripathi (Calcutta School of Tropical Medicine)H-Index: 13
Rapid dissemination of carbapenem-resistant Gram-negative bacteria (CRGNB) is a global threat. Quercetin is known for its antimicrobial activity. In this study, carbapenemase and efflux pump inhibitory activity of quercetin was demonstrated against carbapenem-resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii. Further, molecular docking was performed to elucidate molecular mechanisms of such inhibition. CRGNB, expressing one of the carbapenemase...
Source
#1Milena Tresch (University of Bern)H-Index: 1
#2Meike Mevissen (University of Bern)H-Index: 30
Last. Michael Walkenhorst (Research Institute of Organic Agriculture)H-Index: 12
view all 6 authors...
Medicinal plants have been used traditionally since centuries for wound care and treatment of skin diseases both in human and animals. Skin diseases are one of the most common reasons for owners to take their dog to the veterinarian. The demands for treatment and prophylaxis of these diseases are broad. A wide range of bacteria including antibiotic-resistant bacteria can be involved, making the treatment challenging and bear an anthropo-zoonotic potential. The aim of this review is to systematic...
7 CitationsSource
#1Igor LoncaricH-Index: 14
#2Alexander TichyH-Index: 22
Last. Frank KünzelH-Index: 12
view all 8 authors...
The aim of this study was to detect the prevalence of methicillin-resistant Staphylococcus sp. (MRS) in populations of companion animals that either have previously been exposed or have not been exposed to antibiotic therapy or veterinary facilities, and if owners’ healthcare profession had an influence on colonization with MRS. In addition, the antimicrobial resistance pheno- and genotype were investigated and risks for colonization with MRS were assessed. During this study, 347 nasal swabs (do...
10 CitationsSource
#1Michael T. Sweeney (Zoetis)H-Index: 11
#2Brian V. Lubbers (KSU: Kansas State University)H-Index: 14
Last. Jeffrey L. Watts (Zoetis)H-Index: 29
view all 4 authors...
: Standardized definitions for MDR are currently not available in veterinary medicine despite numerous reports indicating that antimicrobial resistance may be increasing among clinically significant bacteria in livestock and companion animals. As such, assessments of MDR presented in veterinary scientific reports are inconsistent. Herein, we apply previously standardized definitions for MDR, XDR and pandrug resistance (PDR) used in human medicine to animal pathogens and veterinary antimicrobial ...
57 CitationsSource
#1Taina Scheid (University of Rio Grande)H-Index: 1
#2Maira Silmara de Moraes (University of Rio Grande)H-Index: 1
Last. Wania Aparecida Partata (University of Rio Grande)H-Index: 1
view all 8 authors...
We determined the antioxidant potential of fractions obtained from leaves of Schinus terebinthifolius, a medicinal plant known in Brazil as aroeira, to select the fraction with the best yield and antioxidant performance. These qualities were found in the methanol fraction (MeF), which was administered intraperitoneally (20 mg/kg/day) for 3 and 10 days to rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain. The MeF increased the mechanical and thermal thr...
4 CitationsSource
Background This study showed phytochemical composition and evaluates the anti-inflammatory, and analgesic activities of crude extract (CE) and fractions from E. uniflora Linn leaves.
18 CitationsSource
#1Louise Haubert (UFPEL: Universidade Federal de Pelotas)H-Index: 6
#2Isabela Schneid Kroning (UFPEL: Universidade Federal de Pelotas)H-Index: 5
Last. Wladimir Padilha da Silva (UFPEL: Universidade Federal de Pelotas)H-Index: 19
view all 4 authors...
Abstract The aim of this work was to identify at the molecular level the species of coagulase-positive staphylococci isolates from clinical and subclinical bovine mastitis samples in Southern Brazil, and to evaluate the antimicrobial resistance profile, as well as the presence of resistance genes. According to the PCR assay, all 31 isolates were classified as Staphylococcus aureus. The isolates were tested for resistance to penicillin, ampicillin, oxacillin, cefoxitin, cephalothin, ceftiofur, st...
9 CitationsSource
#1Kun Li (Liaoning Normal University)H-Index: 4
#2Yue Lin (Liaoning Normal University)H-Index: 1
Last. Shouyu Wang (Dalian Medical University)H-Index: 15
view all 9 authors...
Background To extract, purify, and identify the effective constituents of aqueous extract of Fructus Chebulae Immaturus, and analyze the bactericidal effects of total tannins.
4 CitationsSource
#1Kimberly A. Bliven (USU: Uniformed Services University of the Health Sciences)H-Index: 4
#2Anthony T. Maurelli (USU: Uniformed Services University of the Health Sciences)H-Index: 47
Selective pressures within the human host, including interactions with innate and adaptive immune responses, exposure to medical interventions such as antibiotics, and competition with commensal microbiota all facilitate the evolution of bacterial pathogens. In this chapter, we present examples of pathogen strategies that emerged as a result of selective pressures within the human host niche and discuss the resulting coevolutionary “arms race” between these organisms. In bacterial pathogens, man...
220 CitationsSource
#1Jose M. Munita (University of Texas at Austin)H-Index: 24
#2Cesar A. Arias (University of Texas at Austin)H-Index: 56
The discovery, commercialization, and routine administration of antimicrobial compounds to treat infections revolutionized modern medicine and changed the therapeutic paradigm. Indeed, antibiotics have become one of the most important medical interventions needed for the development of complex medical approaches such as cutting-edge surgical procedures, solid organ transplantation, and management of patients with cancer, among others. Unfortunately, the marked increase in antimicrobial resistanc...
586 CitationsSource
Cited By0
Newest