The important role of non‐covalent drug‐protein interactions in drug hypersensitivity reactions

Allergy12.40
Volume: 77, Issue: 2, Pages: 404 - 415
Published: Jun 14, 2021
Abstract
Drug hypersensitivity reactions (DHR) are heterogeneous and unusual immune reactions with rather unique clinical presentations. Accumulating evidence indicates that certain non-covalent drug-protein interactions are able to elicit exclusively effector functions of antibody reactions or complete T-cell reactions which contribute substantially to DHR. Here, we discuss three key interactions; (a) mimicry: whereby soluble, non-covalent drug-protein...
Paper Details
Title
The important role of non‐covalent drug‐protein interactions in drug hypersensitivity reactions
Published Date
Jun 14, 2021
Journal
Volume
77
Issue
2
Pages
404 - 415
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