The important role of non‐covalent drug‐protein interactions in drug hypersensitivity reactions
Abstract
Drug hypersensitivity reactions (DHR) are heterogeneous and unusual immune reactions with rather unique clinical presentations. Accumulating evidence indicates that certain non-covalent drug-protein interactions are able to elicit exclusively effector functions of antibody reactions or complete T-cell reactions which contribute substantially to DHR. Here, we discuss three key interactions; (a) mimicry: whereby soluble, non-covalent drug-protein...
Paper Details
Title
The important role of non‐covalent drug‐protein interactions in drug hypersensitivity reactions
Published Date
Jun 14, 2021
Journal
Volume
77
Issue
2
Pages
404 - 415
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