Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells
Abstract
Recent technological advances have enabled massively parallel chromatin profiling with scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here we present ATAC with select antigen profiling by sequencing (ASAP-seq), a tool to simultaneously profile accessible chromatin and protein levels. Our approach pairs sparse scATAC-seq data with robust detection of hundreds of cell surface and intracellular protein markers...
Paper Details
Title
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells
Published Date
Jun 3, 2021
Journal
Volume
39
Issue
10
Pages
1246 - 1258
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