Impact of Tenofovir Alafenamide Vs. Entecavir on Hepatocellular Carcinoma Risk in Patients With Chronic Hepatitis B

Published on Aug 16, 2021
· DOI :10.1007/S12072-021-10234-2
Hye Won Lee22
Estimated H-index: 22
(Yonsei University),
Young Youn Cho14
Estimated H-index: 14
(CAU: Chung-Ang University)
+ 7 AuthorsSoo Young Park75
Estimated H-index: 75
(KNU: Kyungpook National University)
#1Lung-Yi Mak (HKU: University of Hong Kong)H-Index: 13
#2Gavin ClohertyH-Index: 19
Last. Man-Fung Yuen (HKU: University of Hong Kong)H-Index: 93
view all 7 authors...
Background and aims Large-scale comprehensive studies on hepatitis B virus (HBV) RNA in chronic hepatitis B are lacking. We aimed to study HBV RNA profile and its correlation with other viral markers in CHB treatment-naive patients and patients receiving nucleos(t)ide analogues (NA). Approach & results Novel biomarkers including HBV RNA and hepatitis B core-related antigen (HBcrAg) were measured in 388 patients. Of these, 246 were treatment-naive and were categorized into HBeAg-positive chronic ...
12 CitationsSource
#1Laurent Lam (Paris IV: Paris-Sorbonne University)H-Index: 1
#2Hélène FontaineH-Index: 49
Last. Stanislas Pol (University of Paris)H-Index: 102
view all 38 authors...
Abstract Background & Aims: The factors predicting hepatocellular carcinoma (HCC) occurrence in chronic hepatitis B need to be precisely known to improve its detection. We identified pathways and individual predictive factors associated with HCC in the ANRS CO22 HEPATHER cohort. Methods: The study analyzed HBV-infected patients recruited at 32 French expert hepatology centers from August 6, 2012, to December 31, 2015. We excluded patients with chronic HCV, HDV and a history of HCC, decompensated...
3 CitationsSource
BACKGROUND The occurrence of hepatocellular carcinoma (HCC) is a major concern during antiviral therapy for chronic hepatitis B. There are conflicting opinions regarding the effects of entecavir (ETV) and tenofovir disoproxil fumarate (TDF) on HCC prevention. We assessed these two antiviral medications for preventing HCC in treatment-naive patients with chronic hepatitis B. METHODS We conducted a retrospective cohort study using nationwide claims data from the Korea Health Insurance Review and A...
2 CitationsSource
#1Danny ConH-Index: 7
#2Thomas GoodwinH-Index: 1
Last. William KempH-Index: 21
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Both tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are accepted as first-line treatments for chronic hepatitis B (CHB). However, there are few randomized studies comparing their efficacy. The primary aim of this study was to compare the efficacy of TDF and ETV using a network meta-analysis of randomized trials. The secondary aim was to additionally include propensity-matched cohort studies in a conventional meta-analysis. We systematically searched PubMed, EMBASE, Cochrane Library and ...
3 CitationsSource
#1Ka Shing Cheung (HKU: University of Hong Kong)H-Index: 21
#2Lung-Yi Mak (HKU: University of Hong Kong)H-Index: 13
Last. Ching-Lung Lai (HKU: University of Hong Kong)H-Index: 112
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INTRODUCTION Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are recommended as first-line therapies for chronic hepatitis B (CHB) infection. Although both drugs reduce hepatocellular carcinoma (HCC) risk, their comparative effectiveness remains controversial. We aimed to determine whether TDF is superior to ETV in preventing HCC. METHODS PubMed, Embase, and Cochrane Library from inception until June 9, 2020, were searched according to the Preferred Reporting Items for Systematic Reviews...
5 CitationsSource
#1Xiaojuan ChaoH-Index: 20
#2Hui QianH-Index: 3
Last. Wen-Xing DingH-Index: 63
view all 5 authors...
Autophagy is a highly conserved catabolic process that degrades cytosolic proteins and organelles via formation of autophagosomes that fuse with lysosomes to form autolysosomes, whereby autophagic cargos are degraded. Numerous studies have demonstrated that autophagy plays a critical role in the regulation of liver physiology and homeostasis, and impaired autophagy leads to the pathogenesis of various liver diseases such as viral hepatitis, alcohol associated liver diseases (AALD), non-alcoholic...
11 CitationsSource
#1James Fung (HKU: University of Hong Kong)H-Index: 58
#2Lung-Yi Mak (HKU: University of Hong Kong)H-Index: 13
Last. Man-Fung Yuen (HKU: University of Hong Kong)H-Index: 93
view all 14 authors...
BACKGROUND & AIMS: The prognosis in severe acute flares of chronic hepatitis B (AFOCHB) is often unclear. The current study aimed to establish the predictive value using the MELD score for short-term mortality for severe AFOCHB. APPROACH & RESULTS: Patients with severe AFOCHB with bilirubin >50 umol/l, ALT >10x upper limit of normal, and INR >1.5 were included. All patients were commenced on entecavir and/or tenofovir. Laboratory results and MELD scores were pooled to calculate mortality at four...
3 CitationsSource
#1Hyung Joon Yim (KU: Korea University)H-Index: 29
#2Ji Hoon Kim (KU: Korea University)H-Index: 38
Last. Hyun Woong Lee (Yonsei University)H-Index: 18
view all 10 authors...
Clinical practice guidelines are important for guiding the management of specific diseases by medical practitioners, trainees, and nurses. In some cases, the guidelines are utilized as a reference for health policymakers in controlling diseases with a large public impact. With this in mind, practice guidelines for the management of chronic hepatitis B (CHB) have been developed in the United States, Europe, and Asian-Pacific regions to suggest the best-fit recommendations for each social and medi...
13 CitationsSource
#1Yeonjung HaH-Index: 9
#2Young Eun ChonH-Index: 14
Last. Seong Gyu HwangH-Index: 22
view all 5 authors...
Conflicting results have been reported regarding which of entecavir (ETV) or tenofovir disoproxil fumarate (TDF) is associated with better outcomes. Chronic hepatitis B patients who started ETV or TDF between 2010 and 2015 were analysed. The primary outcomes were hepatocellular carcinoma and death and transplantation. The impact of the treatment on the primary outcomes was analysed using Cox proportional hazards models in the entire and propensity score-matched cohorts. A total of 404 patients (...
3 CitationsSource
#1Sang Min Yoon (UOU: University of Ulsan)H-Index: 25
#2So Yeon Kim (UOU: University of Ulsan)H-Index: 37
Last. Han Chu Lee (UOU: University of Ulsan)H-Index: 55
view all 10 authors...
Background/Aims Stereotactic body radiation therapy (SBRT) is used as an alternative ablative treatment in patients with hepatocellular carcinoma (HCC) not suitable for curative treatments. The purpose of this prospective study was to evaluate the long-term efficacy of SBRT for small (≤5 cm) HCCs. Methods A phase II, single-arm clinical trial on SBRT for small HCCs was conducted at an academic tertiary care center. The planned SBRT dose was 45 Gy with a fraction size of 15-Gy over 3 consecutive ...
15 CitationsSource
Cited By1
#1Masataka Tsuge (Hiroshima University)H-Index: 34
Chronic hepatitis B virus (HBV) infection is a worldwide health problem leading to severe liver dysfunction, including liver cirrhosis and hepatocellular carcinoma. Although current antiviral therapies for chronic HBV infection have been improved and can lead to a strong suppression of viral replication, it is difficult to completely eliminate the virus with these therapies once chronic HBV infection is established in the host. Furthermore, chronic HBV infection alters intracellular metabolism a...