'Hypericum brasiliense: bactericidal and antibiofilm activity against Staphylococcus aureus in vitro'.

Published on Jun 2, 2021in Natural Product Research2.158
· DOI :10.1080/14786419.2021.1915306
Renata Freire Alves Pereira5
Estimated H-index: 5
(Federal Fluminense University),
Lialyz Soares Pereira Andre2
Estimated H-index: 2
(Federal Fluminense University)
+ 6 AuthorsFábio Aguiar-Alves8
Estimated H-index: 8
(Federal Fluminense University)
Staphylococcus aureus is considered the most common opportunistic pathogen in humans, capable of forming biofilm, increasing the chances of antibiotic resistance and causes several chronic diseases. Biodiversity is a source of inspiration in the search for new agents against these microorganisms. Hitherto, the efficacy of Hypericum sp. extracts as an antibacterial agent has already been demonstrated against Gram-positive and Gram-negative bacteria. In this study, we observed that until 4 µg/mL, the Hypericum brasiliense extract showed bactericidal activity against a clinical multidrug-resistant S. aureus strain (HU25) and also inhibited biofilm formation at 1/2xMIC (confirmed by SEM) and 1/4xMIC. The extract was also proportionally active against 6 h-preformed biofilm to its concentration (1/2xMIC, 1/4xMIC, p value ≤ 0.05). These promising results make Hypericum brasiliense extract a strong candidate to treat S. aureus infections, including anti-biofilm therapy.
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