Spread‐out Bragg peak proton FLASH irradiation using a clinical synchrocyclotron: Proof of concept and ion chamber characterization

Purpose The purpose of this work is to (a) demonstrate the feasibility of delivering a spread‐out Bragg peak (SOBP) proton beam in ultra‐high dose rate (FLASH) using a proton therapy synchrocyclotron as a major step toward realizing an experimental platform for preclinical studies, and (b) evaluate the response of four models of ionization chambers in such a radiation field. Methods A clinical Mevion HYPERSCAN ® synchrocyclotron was adjusted for...