Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation
Abstract
Smoothened is a key receptor of the hedgehog pathway, but the roles of Smoothened in cardiac development remain incompletely understood. In this study, we found that the conditional knockout of Smoothened from the mesoderm impaired the development of the venous pole of the heart and resulted in hypoplasia of the atrium/inflow tract (IFT) and a low heart rate. The blockage of Smoothened led to reduced expression of genes critical for sinoatrial...
Paper Details
Title
Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation
Published Date
Jun 1, 2021
Journal
Volume
11
Issue
6
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