Maternal periconceptional folic acid supplements use and fetus risk for limb defects

Background Associations between the periconceptional folic acid only (FAO) or multiple micronutrients containing folic acid (MMFA) supplementation and risk for limb defects are inconsistent. Objective To explore the association between periconceptional folic acid supplements use and risk for limb defects, including clubfoot, polydactyly, syndactyly, and limb deficiencies. Methods Data were derived from a cohort based on a pregnancy registry in a...