Synergistic sequence contributions bias glycation outcomes
Abstract
The methylglyoxal-derived hydroimidazolone isomer, MGH-1, is an abundant advanced glycation end-product (AGE) associated with disease and age-related disorders. As AGE formation occurs spontaneously and without an enzyme, it remains unknown why certain sites on distinct proteins become modified with specific AGEs. Here, we use a combinatorial peptide library to determine the chemical features that favor MGH-1. When properly positioned, tyrosine...
Paper Details
Title
Synergistic sequence contributions bias glycation outcomes
Published Date
Jun 3, 2021
Journal
Volume
12
Issue
1
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