Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer
Abstract
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited targeted therapeutic options. A defining feature of TNBC is the propensity to metastasize and acquire resistance to cytotoxic agents. Mitogen activated protein kinase (MAPK) and extracellular regulated kinase (ERK) signaling pathways have integral roles in cancer development and progression. While MEK5/ERK5 signaling drives mesenchymal and migratory cell...
Paper Details
Title
Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer
Published Date
May 18, 2021
Journal
Volume
8
Pages
61 - 71
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