The Association between Polluted Neighborhoods and TP53-Mutated Non–Small Cell Lung Cancer

Poor patients often reside in neighborhoods of lower socioeconomic status (SES) with high levels of airborne pollutants. They also have higher mortality from non-small cell lung cancer (NSCLC) than those living in wealthier communities. We investigated whether living in polluted neighborhoods is associated with somatic mutations linked with lower survival rates, i.e., TP53 mutations.In a retrospective cohort of 478 patients with NSCLC treated at...