Islet Epigenetic Impacts on β-Cell Identity and Function.
Abstract
The development and maintenance of differentiation is vital to the function of mature cells. Terminal differentiation is achieved by locking in the expression of genes essential for the function of those cells. Gene expression and its memory through generations of cell division is controlled by transcription factors and a host of epigenetic marks. In type 2 diabetes, β cells have altered gene expression compared to controls, accompanied by...
Paper Details
Title
Islet Epigenetic Impacts on β-Cell Identity and Function.
Published Date
Jun 1, 2021
Journal
Volume
11
Issue
3
Pages
1961 - 1978
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Notes
History