Impaired Behavioral Pattern Separation in Refractory Temporal Lobe Epilepsy and Mild Cognitive Impairment.

Published on Jun 3, 2021in Journal of The International Neuropsychological Society2.892
路 DOI :10.1017/S1355617721000734
Sanam J. Lalani3
Estimated H-index: 3
(UCSF: University of California, San Francisco),
Anny Reyes10
Estimated H-index: 10
(UCSD: University of California, San Diego)
+ 8 AuthorsCarrie R. McDonald39
Estimated H-index: 39
(UCSD: University of California, San Diego)
Sources
Abstract
OBJECTIVE Episodic memory impairment and hippocampal pathology are hallmark features of both temporal lobe epilepsy (TLE) and amnestic mild cognitive impairment (aMCI). Pattern separation (PS), which enables the distinction between similar but unique experiences, is thought to contribute to successful encoding and retrieval of episodic memories. Impaired PS has been proposed as a potential mechanism underling episodic memory impairment in aMCI, but this association is less established in TLE. In this study, we examined behavioral PS in patients with TLE and explored whether profiles of performance in TLE are similar to aMCI. METHOD Patients with TLE, aMCI, and age-matched, healthy controls (HCs) completed a modified recognition task that relies on PS for the discrimination of highly similar lure items, the Mnemonic Similarity Task (MST). Group differences were evaluated and relationships between clinical characteristics, California Verbal Learning Test-Second Edition scores, and MST performance were tested in the TLE group. RESULTS Patients with TLE and aMCI demonstrated poorer PS performance relative to the HCs, but performance did not differ between the two patient groups. Neither the side of seizure focus nor having hippocampal sclerosis affected performance in TLE. However, TLE patients with clinically defined memory impairment showed the poorest performance. CONCLUSION Memory performance on a task that relies on PS was disrupted to a similar extent in TLE and aMCI. The MST could provide a clinically useful tool for measuring hippocampus-dependent memory impairments in TLE and other neurological disorders associated with hippocampal damage.
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#1Michelle I Nash (USAFA: United States Air Force Academy)H-Index: 1
#2Cooper B. Hodges (BYU: Brigham Young University)H-Index: 4
Last. C. Brock Kirwan (BYU: Brigham Young University)H-Index: 28
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Episodic memory depends on the computational process of pattern separation in order to establish distinct memory representations of similar episodes. Studies of pattern separation in humans rely on mnemonic discrimination tasks, which have been shown to tax hippocampal-dependent pattern separation. Although previous neuroimaging research has focused on hippocampal processing, little is known about how other brain regions, known to be involved in recognition memory performance, are involved in mn...
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#1Sara Pishdadian (York University)H-Index: 3
#2N.V. Hoang (U of T: University of Toronto)H-Index: 1
Last. R.S. Rosenbaum (York University)H-Index: 4
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Mnemonic discrimination, the process of distinguishing highly similar items in memory, relies on the dentate gyrus (DG) subregion of the hippocampus. The Mnemonic Similarity Task (MST) has been shown to be a sensitive behavioral measure of mnemonic discrimination that is in wide use ( Liu et al., 2016 ). In this study, we evaluate the sensitivity and specificity of the MST in community-dwelling older adults who were administered the Montreal Cognitive Assessment (MoCA), a well-established screen...
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#1Chris M. Foster (UNC: University of North Carolina at Chapel Hill)H-Index: 7
#2Kelly S. Giovanello (UNC: University of North Carolina at Chapel Hill)H-Index: 27
Several prominent domain general theories (e.g., processing speed and inhibitory function) have been developed to explain cognitive changes associated with aging. A bias to "pattern complete" in aging has also been suggested to account for some of the age-related changes in episodic memory. The current experiments test whether domain-general processes of cognitive aging moderate age-related performance decrements on the mnemonic similarity task, a task thought to rely on hippocampal pattern sepa...
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#1Claudia Poch (Complutense University of Madrid)H-Index: 14
#2Rafael ToledanoH-Index: 13
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Abstract Mesial temporal lobe epilepsy (mTLE) is a neurological disorder associated with histopathological changes in different subfields of the hippocampus. These alterations have been associated with memory difficulties. In this study, we tested the hypothesis that these difficulties stem on mnemonic discrimination impairment due to a reduced ability to make similar representations more distinct, leading to an increased susceptibility to interference. With this aim, we used a visual mnemonic d...
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Computerized cognitive assessments may improve Alzheimer鈥檚 disease (AD) secondary prevention trial efficiency and accuracy. However, they require validation against standard outcomes and relevant biomarkers. To assess the feasibility and validity of the tablet-based Computerized Cognitive Composite (C3). Cross-sectional analysis of cognitive screening data from the A4 study (Anti-Amyloid in Asymptomatic AD). Multi-center international study. Clinically normal (CN) older adults (65鈥85; n=4486) Pa...
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#2C. Brock Kirwan (BYU: Brigham Young University)H-Index: 28
Last. Craig E.L. Stark (UCI: University of California, Irvine)H-Index: 54
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The hippocampus is critical for learning and memory, relying in part on pattern separation processes supported by the dentate gyrus (DG) to prevent interference from overlapping memory representations. In 2007, we designed the Mnemonic Similarity Task (MST), a modified object recognition memory task, to be highly sensitive to hippocampal function by placing strong demands on pattern separation. The MST is now a widely used behavioral task, repeatedly shown to be sensitive to age-related memory d...
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#1Patrick S. R. Davidson (U of O: University of Ottawa)H-Index: 24
#2Petar Sefik Vidjen (U of O: University of Ottawa)H-Index: 2
Last. Charles A. Collin (U of O: University of Ottawa)H-Index: 15
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OBJECTIVES: Pattern separation in memory encoding entails creating and storing distinct, detailed representations to facilitate storage and retrieval. The Mnemonic Similarity Task (MST; Stark, S. M., Yassa, M. A., Lacy, J. W., & Stark, C. E. [2013]. A task to assess behavioral pattern separation [BPS] in humans: Data from healthy aging and mild cognitive impairment. Neuropsychologia, 51, 2442-2449) has been used to argue that normal aging leads to pattern separation decline. We sought to replica...
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#1Mark D. Zuppichini (UTD: University of Texas at Dallas)H-Index: 4
#2Joshua Sandry (MSU: Montclair State University)H-Index: 2
Abstract Memory impairment and hippocampal atrophy are common in multiple sclerosis (MS). In the present pilot study, we investigate whether the mnemonic process of pattern separation is impaired and a predictor of hippocampal volume in relapsing remitting MS. MS participants and healthy controls completed the Mnemonic Similarities Task (MST) along with traditional neurocognitive assessments of memory. 3T structural magnetic resonance imaging was used to estimate whole hippocampal volumes (main ...
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: With advances in healthcare and an ageing population, the number of older adults with epilepsy is set to rise substantially across the world. In developed countries the highest incidence of epilepsy is already in people over 65 and, as life expectancy increases, individuals who developed epilepsy at a young age are also living longer. Recent findings show that older persons with epilepsy are more likely to suffer from cognitive dysfunction and that there might be an important bidirectional rel...
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Abstract Background Converging evidence from neuroimaging and postmortem studies suggests that hippocampal subfields are differentially affected in schizophrenia. Recent studies report dentate gyrus dysfunction in chronic schizophrenia, but the underlying mechanisms remain to be elucidated. Here we sought to examine if this deficit is already present in first-episode psychosis, and if N -methyl-D-aspartate receptor hypofunction, a putative central pathophysiological mechanism in schizophrenia, e...
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