Royal jelly fatty acids bioprofiling using TLC-MS and digital image analysis coupled with chemometrics and non-parametric regression for discovering efficient biomarkers against melanoma

Published on May 24, 2021in RSC Advances3.119
· DOI :10.1039/D1RA00580D
Reham S. Ibrahim5
Estimated H-index: 5
,
Alaa A. El-Banna1
Estimated H-index: 1
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Abstract
References32
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#1Mohamed A. Korany (Alexandria University)H-Index: 15
#2Marwa S. Moneeb (Alexandria University)H-Index: 7
Last. Alaa A. El-Banna (Alexandria University)H-Index: 1
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A new, simple, stability-indicating high-performance thin-layer chromatography method was developed for the quantification of 10-hydroxy-2-decenoic acid (10-HDA) in some royal jelly products marketed in Egypt. The used solvent system was chloroform:acetic acid (10:1, v/v) and the bands were measured densitometrically at 210 nm. First- and second-derivative treatments of the data were performed. The present study shows a comparison between three statistical regression methods for handling data: p...
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#1Chistina Virgiliou (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
#2Dimitris Kanelis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 3
Last. Georgios Theodoridis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 54
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Abstract Royal Jelly (RJ) constitutes one of the most popular beehive products and for this reason the use of inexpensive sweeteners during its production remains an important quality issue. In the present study we report results of metabolic profiling of RJ samples obtained after the application of artificial bee-feeding using different feeding protocols. The hydrophilic content of RJ samples was assessed by applying (HILIC)UPLC-MS/MS. In total 96 crude RJ samples were analysed with the develop...
9 CitationsSource
#1Reham S. Ibrahim (Alexandria University)H-Index: 5
#2Asmaa Khairy (Alexandria University)H-Index: 2
Last. Asmaa M. SalmanH-Index: 1
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Abstract Sprouting is a commonly applied food processing practice specially in Western countries. Tracking the impact of sprouting of Medicago sativa L. (alfalfa) seeds on their phytochemical composition and curative efficacy was implemented in the current study. Sprouting of alfalfa seeds under controlled conditions for eleven days was performed in a biochemical incubator and three samples were randomly taken each day. A total of thirty-six samples (three ungerminated seeds and thirty-three spr...
2 CitationsSource
#1Maroula G. Kokotou (UoA: National and Kapodistrian University of Athens)H-Index: 14
#2Christiana Mantzourani (UoA: National and Kapodistrian University of Athens)H-Index: 3
Last. George Kokotos (UoA: National and Kapodistrian University of Athens)H-Index: 33
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The lipidome of royal jelly (RJ) consists of medium-chained (8–12 carbon atoms) free fatty acids. We present herein a liquid chromatography-high resolution mass spectrometry (HRMS) method that permits the determination of RJ fatty acids and at the same time the detection of suspect fatty acids. The method allows for the direct quantification of seven free fatty acids of RJ, avoiding any derivatization step. It was validated and applied in seven RJ samples, where the major RJ fatty acid trans-10-...
3 CitationsSource
Aging is a natural phenomenon that occurs in all living organisms. In humans, aging is associated with lowered overall functioning and increased mortality out of the risk for various age-related diseases. Hence, researchers are pushed to find effective natural interventions that can promote healthy aging and extend lifespan. Royal jelly (RJ) is a natural product that is fed to bee queens throughout their entire life. Thanks to RJ, bee queens enjoy an excellent reproductive function and lengthene...
34 CitationsSource
#1Rasha M. AllamH-Index: 2
#2Ahmed M. Al-Abd (KAU: King Abdulaziz University)H-Index: 25
Last. Ashraf B. Abdel-Naim (KAU: King Abdulaziz University)H-Index: 28
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Abstract Sphingolipids are critical regulators of tumor microenvironments and play an important role in estrogen-dependent cancers. Estrogen and estrogen metabolites were found to be involved in prostate cancer. Fingolimod (FTY720) is a sphingokinase-1 (SphK1) inhibitor with anticancer properties against various tumor cell types. Herein, we investigated the interference of FTY720 with the cross talk between sphingolipid metabolism and estrogen metabolism within prostate cancer cells. FTY720 show...
14 CitationsSource
#1Hui-Fang ChiuH-Index: 11
#2Bo-Kai Chen (CSMU: Chung Shan Medical University)H-Index: 1
Last. Chin-Kun Wang (CSMU: Chung Shan Medical University)H-Index: 13
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AbstractContext: Royal jelly (RJ) has been reported for its health promoting factors such as antioxidant, anti-inflammatory and lipid lowering activities.Objective: The present randomized, placebo-controlled study examines the hypolipidemic beneficial effect of RJ through evaluating anthropometric measurements, lipid profile and various hormone levels in mildly hypercholesterolemic participants.Materials and methods: Forty subjects with mild hypercholesterolemia (180–200 mg/dL) were randomly sel...
19 CitationsSource
#1Chi-Chung Peng (NFU: National Formosa University)H-Index: 1
#2Hui-Tzu Sun (NFU: National Formosa University)H-Index: 1
Last. Jen-Chieh LiH-Index: 1
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Background It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting activity of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly of Apis mellifera.
13 CitationsSource
#1Petar RistivojevićH-Index: 18
#2Jelena Trifković (University of Belgrade)H-Index: 18
Last. Dušanka Milojković-Opsenica (University of Belgrade)H-Index: 20
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Abstract Considering the introduction of phytochemical fingerprint analysis, as a method of screening the complex natural products for the presence of most bioactive compounds, use of chemometric classification methods, application of powerful scanning and image capturing and processing devices and algorithms, advancement in development of novel stationary phases as well as various separation modalities, high-performance thin-layer chromatography (HPTLC) fingerprinting is becoming attractive and...
28 CitationsSource
#1Eva Gorrochategui (CSIC: Spanish National Research Council)H-Index: 8
#2Joaquim Jaumot (CSIC: Spanish National Research Council)H-Index: 27
Last. Romà Tauler (CSIC: Spanish National Research Council)H-Index: 74
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Abstract Data analysis is a very challenging task in LC-MS metabolomic studies. The use of powerful analytical techniques (e.g., high-resolution mass spectrometry) provides high-dimensional data, often with noisy and collinear structures. Such amount of information-rich mass spectrometry data requires extensive processing in order to handle metabolomic data sets appropriately and to further assess sample classification/discrimination and biomarker discovery. This review shows the steps involved ...
117 CitationsSource
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