Receptor tyrosine kinases and cancer: oncogenic mechanisms and therapeutic approaches
Abstract
Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK dysregulation have been identified, resulting in multiple cancer types displaying 'oncogenic addiction' to RTKs. As a result, RTKs have represented a major class for targeted therapeutics over the past two decades, with numerous small molecule-based tyrosine kinase...
Paper Details
Title
Receptor tyrosine kinases and cancer: oncogenic mechanisms and therapeutic approaches
Published Date
Jun 2, 2021
Journal
Volume
40
Issue
24
Pages
4079 - 4093
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